16.7mol，1.0mol/LinTHF)slowlyandtheinternaltemperaturewascontrolledbelow-30°C.Afteraddition，thereactionwasheldbetween-35and-40°Cfor20min.Thereactionwasquenchedatthesametemperaturewith19%H3PO4solution(17kg)slowlyandtheinternaltemperaturewascontrolledbelow30°C.ThereactionwasdilutedwithEtOAc(17kg).Afterthephaseseparation。

0.05mmol)，dppf(33.3mg，0.06mmol)，Zn(13.mg，0.2mmol)，Zn(CN)2(47.0mg，0.4mmo1)，DMAP(91.6mg，0.75mmol)，KI(41.5mg，0.25mmol)4-甲氧基甲横酸酯(107mg，0.5mmol)。

andp-toluenesulfonylchloride(7.2g，38.1mmol)inpyridinewasadded.Thesolutionwaskeptat4°Cfor2weeks.Thesolutionwaspouredintoicewater，filtered，andyieldedagraywhiteprecipitatewhichwasdriedinvacuotoafford5.9g(>ofproduct).Toasolutionof2-tosyloxy-1。